My first trip to the barrows was a bit of a hit and miss, almost dying twice.
I've since gone through 30 odd times and more or less got a rhythm going, and as such thought I'd put up a bit of a guide for it.
Below is my inventory and gear setup. Pretty basic, you can swap and change as you like, but basically you will need:
- mage gear (Ahrim's/Akrisae's/Gano)
- A weapon for each class, I have Polypore staff for mage, Maul for melee and Crystal Bow for range
- Any shield if you want to use the rejuvenate ultimate
- Some prayer potions, should only need if you get a tough brother in the tunnels
- Food, for eating lol
- Runes, I'm using fire surge
- A way to get there (Drakkan's medallion is the best)

Each of the Brothers has his own specific weakness as below:
Darrock - Magic (fire)
verac - Magic (earth)
Torag - Magic (water)
Guthan - Magic (air)
Akrisae - Ranged (bolts)
ahrim - Ranged (arrows)
karil - Melee (stab)
I've setup my action bars as below:
Melee (for Karil)

Ranged (for Ahrim)

Magic (for Dharok, Verac, Torag and Guthan)

Hybrid (for Akrisae)

The hybrid bar allows switching attack styles without switching action bars, I've found the most effective way to kill Akrisae is to use basic abilities from magic and ranged to build adrenaline, and then unleash the incendry shot ultimate to finish him off.
Tips:
All 3 attack styles has 3 sec cooldown bread and butter ability (Wrack for mage, Slice for melee and Piercing shot for range), to build adrenaline quickly use these abilities in-between other basics (Example: Wrack>Dragonbreath>Wrack>Combust>Wrack>Chains etc..) this will give you access to stronger threshold abilities more quickly.
On the weaker brothers torag, guthan, karil and ahrim save your adrenaline to use rejuvenate after the fight.
The creatures in the tunnels are all weak to Magic, however melee is almost as effective on them.
For the most part the barrows is much like it was before, however it does pay much more attention to the combat triangle.
I've attached a video of a quick barrows run to show this strategy in action.

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