After the update, I've been having trouble switching weapons and picking up items. Half the time I click something it doesnt responds until i click it like 3 times. Do you guys get this too?

Yes, I'm having trouble clicking too. Like if i want to pick something up or switch to my inventory or something like that, there is a delay or I have to click it again if I moved the mouse away too fast. I've heard that with prayers there is a .6 second delay so I don't know if other things are like that but from what I read, they may fix that. But yes, I'm having the same problems as you.

I got the same problem, when I click the numbers for my Bank pin, it clicks on the same ox twice.. its not all the time though, but its anoying :x

It'ts a know bug. JAgex says it will be fixed at the next update, and from their cryptic message, safespotting too.