1 of the brothers will pop out when you open the chest so no. If you plan on getting somthing u need more than 1 trip Buying a d med for 550-600k is way cheaper than making 10 trips to barrows The brothers that you kill you are more likley to get somthing from them i went to barrows and didnt kill the mage and i fought gunthans right when i open chest and i got war spear