Alright, I've looked at a bunch of guides for Rogue Trader and this is making me sooooo mad.

 

Why are my runes so expensive? Everyone talks about making soo much profit off them but cosmics are 230 ea, natures 380 ea just as examples. The only rune for a profit is death runes for me

It's outdated. When it was released it was quite good money.

If you are talking about Rune Sudoku, to make a profit you have to buy all the runes for whatever amount of cash he asks. It is not a good profit unless you can do the hardest sudokus at an extremely quick pace.