either buy from other players or make with herblore (if ur talking about the poison that doesnt do anything (the one in the green bottle) theres some in the draynor mansion
there monster drops, some of the monsters that drop are: Ice Queen -lvl 111 Earth Warrior -lvl 51 Hobgoblin -lvl 42 Hobgoblin -lvl 28 Zombie -lvl 24 hope that helps
everytime u hit a rock with a rune pickaxe, u hit it like 21 times until u have to click the rock again, that is if u dont get the ore sooner, addy is like 15 or so, not sure though cuz it dont take me that many swings to get the ore