It'll depend alot upon what your trying to do. If your just going for fast kills i'd go in with void and either your best dual wielding melle weapons and use momentum if you plan on afking, or for slightly faster kills your maul. and bring your chaotic staff and runes just for stuff weak to mage. for range i bring royal crossbow and if you want something cheaper bring a crystal bow. Overloads aren't worth it. Just use super medallion, some prayer potions, and some food. I use a Uni with scrolls, but an elemental titan might speed up kills and offer slight healing I did this post EOC, but i think it'll still be a great tactic if your trying to get unlock everything like i was. First unlock the achiements that require you to reach certain floors to unlock dominion sword and crossbow. (use something other than void for climber if you want since they can disable chestplates) Then just go in to endurance mode with void and the above set up. get a kill claim reward repeat. (this is to claim all the journal pages by the time you reach 450 kills) Keep any bombs and dominion weapons you get, but you can turn any potions and food into xp. After collecting all 20 journal pages, start aiming to last as long as you can to beat the upper level bosses. Id try with the same equipment, but some bosses will require some different setups. As you get closer to 400 kills i'd start changing your inventory to best fit the bosses you have left. If you have any questions for specific bosses or anything just post here or pm me in game and i can try to help