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Bauke

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Posts posted by Bauke

  1. We're also planning to release sequels to two of our older storylines and some guild-oriented content in November and December.

    Me like.

     

    We're really trying to focus on higher levels and endgame content at the moment, so I see a great deal of next year's updates being suitable for those players with 70+ in skills, including content for the uber-levelled players (90+).

    Even more like.

  2. I've spent over 170 days playing this game... and it makes me want to cry. If I'm not playing Runescape, I'm randomly browsing teh interwebs, watching movies online or at the theaters, or just watching TV. All of those things are great, but Runescape eats up my time like no other. I'm doing good in school and I'm not a no-life nub in school with no friends B) :^o , but if I didn't have Runescape in my life I'd be so much better off. I'd actually get homework done at home (I know, homework at home?).

     

    Runescape isn't the problem. You are. You don't have enough responsibility and maturity to know when it's time to put down the keyboard, and despite your visions of lollipop dreams, there is no magical land that Runescape pulls you away from, you'll find that life outside of Runescape isn't much different than life inside of it, because it is a video game.

     

    You know how you have a problem with Runescape? When you create a thread on a fansite where you whine about how your life would be better without it, acknowledging that you're too lazy to do something about it, saying far more about your character and integrity than your plainly laid description of yourself.

     

    If you think Runescape is such a detriment to you, put down they keyboard. Everyone has their little habits, be grateful yours isn't heroin or cocaine.

    This.

  3. Very smart. They make a bunch of people enter RSC, then lock those to one server. Next time they'll probably assign world 3 for the new people. It keeps the servers free from bots as new people can't ever enter the server that was previously opened. Individual botters that to slip in can simply be kicked whenever they're caught.

  4. People think crippling themselves gives them extra respect. Usually, those level 3 skillers only have easy 99s. I reckon they quit after they get 99 cooking, since it's a ridiculous way to train skills.

     

    Some people claim they like the challenge that being level 3 brings. Though that always makes me wonder why they haven't gotten all skills at 99 and beyond on their main.

  5. Skiller worlds, a new feature Jagex added to the game.

    These worlds have absolutly nothing special about them besides for the fact that entering one requires atleast 1000 total level.

     

    This causes quite a few problems and seems unreasonable to me.

     

     

    For once, it is possible to enter such a world if all your skills are 41-42 (which means, if all are 42, a tad over 12.7M total exp). Well, on my level 3 skiller my total level is not even 500, yet my total exp exceeds 40M. Morever, it is possible to have 126 total level with over 200M total exp! I highly doubt anyone with less than 13M total exp deserves that more than my skiller, for example.

     

    It's your own responsibility that you decide to not train skills. Don't expect Jagex to feel sorry for you not being able to enter that world when you personally decide you want to cripple yourself.

  6. The german twitter hint got released today:

    Der Unheilsprophet von #RuneScape weiß: "Wer Wind sät, wird Sturm ernten." ~mod_vero

     

    Translation:

    The Doomsayer of RuneScape knows: "They sow the wind and reap the whirlwind."

    Isn't there a better way to put this in English? It basically means "if you cause a fuss, you're most likely to face even more aggressive responses".

     

    Something like that. The wind and whirlwind are a metaphor.

  7. Although I've been playing RS pretty much from the start, I wouldn't ever want to go back. It's just an extremely outdated version of the game. I don't know why I'd want worse graphics, less content and less handy features.

     

    Cause 3 hitting is for winners!

     

    My answer is I never lost access. Woop woop :thumbsup:

    3 hitting isn't that great for someone who would just run if being pk'ed :P

  8. That doesn't mean there were no slaves involved. You fail to mention that, although your sources even state that there were probably slaves involved. One of them even states that there were "undoubtedly" slaves involved.

     

    Keep reading, yeah.

  9. Just pointing out, that the pyramids weren't build by slaves, or any form of induced labour.

     

    Egyptians built the pyramids, normal citizens. Common labourers.

    Normal citizens.. which were used as slaves. The workers that had to built the inside of the pyramid and knew the layout of the pyramid were actually trapped inside, so that they couldn't ever tell anyone else about the way the pyramid was layed out inside. Just to give an example. It wasn't exactly a normal work environment.

     

    As for the topic start, I wish people would stop making up stories. Religion is bad enough as it is. We don't need more fairy tales.

  10. They knocked out the virulent genes of HIV and merely used it as a vector (a trojan horse if you will) to take the gene of interest into myelin-forming stem cells in bone marrow.

     

    It's not like they just infected these kids with HIV, you know. (read the article people, please)

    Yes, exactly.

     

    It's not like this is new. Yes, HIV is not often used (adenoviruses and the semliki-forest virus are often candidates), but the whole procedure has been used for a long time. However, what is interesting here is that they actually pulled it off to make stem cells migrate to the brain and differentiate into some sort of oligodendrocytes (so I have to correct you here, a myelin-forming cell is no stem cell anymore. The article is just plain wrong). Also, your links stated that the viruses were transformed into basic lentiviral vectors which were originally derived from HIV. Lentiviral factors are actually quite common. So basically it's not that exciting although the HIV derived part is new.

     

    HIV is actually a quite logical virus to make into a vector. HIV can infect lymphocytes which are derived from the blood. So they're probably prone to infect the blood stem cells (hematopoietic stem cells) in the bone marrow.

     

    Oh and "stem cell" might just not be the correct term. The cells that were selected are CD34+ cells. A marker which is expressed on hematopoietic stem cells, but it is not exclusive for these HSCs.

     

    What I'm still wondering about is if they did something to direct the blood cells to the brain.. some sort of chemoattractant or cause disruption of the blood brain barrier. I wonder how they made the transduced cells actually go to the place where they are needed. The article states only 15% of the cells produced the right protein, though the neurological symptoms already declined. Maybe if they were to optimize it by selectively sending the cells to the brain, this would be an even bigger success. Secondly, I don't get why they only sorted the cells for the CD34+ marker. Other markers for HSCs are known and could be used to create a more pure culture of HSCs.

     

    Interesting.

  11. EDIT: Damnit doom, you and I are too alike. I spent a few minutes writing exactly what you did.

     

    Might as well disregard this, I guess. But, you know what? I would like to emphasize that. You're fine. It's all in your head.

    Is that what you say to schizophrenic people?

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