In some edge cases even though the potions are more expensive you need to use fewer doses which saves you money, because the supreme overloads have a 6 minute timer. The main example which comes to mind is mage araxxor path 1. For those that don't know, the mage spider applies a debuff which drains overloads more quickly. What this means is that even though my kills on path 1 are typically around 8:30, I usually have to take a third sip of overload. Then, the rest of that potion is wasted while banking. With the supreme pots it's doable to do a kill, even with poor RNG, in 2 doses of supreme ovl. Another good example is nex duos. I haven't duoed nex in a long time, but the last time I did, my kills usually were just a bit over 1 overload dose long.