I was told by MMG that relative (go up 10 pixels) movement = okay, absolute (go to pixel-x,y) is not okay. This was a couple years back, but I haven't seen any proof they've changed that stance since then. EDIT @ Vork below There are 2 main rules for the use of mousekeys a) 1 input = 1 output b) no absolute movement If you fulfil those restrictions, you're good to go. So yeah, you could hotkey everything but it wouldn't really be at all useful.